Gintama
In a world where aliens have invaded Edo Period Japan, skyscrapers, trains and motor bikes have replaced the simple life of Earth inhabitants. One man however, still carries the soul of a samurai, Gintoki Sakata, otherwise known as Yorozuya Gin-san. As reckless as he is, Gintoki carries his own resolve and is ready to take on any challenge with his fellow companions.

Season 5 · Episode 2 ·
Everyone Looks Pretty Grown Up After Summer Break
As Katsura and Kyubei fight for the title of the best transgendered, Shinpachi leaves to find that the Shinsengumi members also suffered a sudden change in their selves; Sogo Okita is the leader from the group and orders him and Toshiro Hijikata, Sagaru Yamazaki to attack the Yorozuya. As the three leave, Hijikata knocks out Yamazaki, as he was faking his change. He and Shinpachi learn that an invasion of parasite aliens is responsible for change to their friends and proceed to destroy them. However, they find problems in the outcome, and both Hijikata and and Shinpachi are knocked out in the process, with Gintoki being actually only person without a parasite.
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Episode 2 of season 5 of Gintama: “Everyone Looks Pretty Grown Up After Summer Break”. Aired 2011-04-11. Watch it online free on ZapFlix.