Bewitched
Samantha Stephens is a seemingly normal suburban housewife who also happens to be a genuine witch, with all the requisite magical powers. Her husband Darrin insists that Samantha keep her witchcraft under wraps, but situations invariably require her to indulge her powers while keeping her bothersome mother Endora at bay.

Season 8 · Episode 19 ·
Serena's Youth Pill
Serena returns for the last time and babysits with Tabitha and Adam. Larry comes by to return a golf club and Serena does an Abby Cunningham on him. Larry hurries off, but not before Serena gives him a pill to be young and active (pre-Viagra!). It makes him younger, all right, by ten years! Larry gets even younger and younger and everyone is very worried about him. Serena gives him an antidote which turns him back to normal.
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Episode 19 of season 8 of Bewitched: “Serena's Youth Pill”. Aired 1972-02-05. Watch it online free on ZapFlix.