Johnny Test
Young Johnny is gung-ho and full of courage. Johnny's brainiac twin sisters, Susan and Mary, use Johnny as their guinea pig for their outrageous scientific experiments. If they can dream it up, Johnny will do it; as long as his genetically engineered super dog, Dukey, can come along.

Season 4 · Episode 1 ·
Johnny's New Baby Sisters
Susan and Mary purposely turn themselves into babies while the parents are out, and Johnny has to keep them safe from the irresponsible babysitter Gil; this interferes with a party he and Dukey had been planning.
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Episode 1 of season 4 of Johnny Test: “Johnny's New Baby Sisters”. Aired 2009-09-10. Watch it online free on ZapFlix.