Johnny Test
Young Johnny is gung-ho and full of courage. Johnny's brainiac twin sisters, Susan and Mary, use Johnny as their guinea pig for their outrageous scientific experiments. If they can dream it up, Johnny will do it; as long as his genetically engineered super dog, Dukey, can come along.

Season 4 · Episode 11 ·
Dukey Jekyll and Johnny Hyde
Dukey drinks a liquid which makes him turn into a monster. To make matters worse, a dog catcher (and later Mr. Black and Mr. White) are after him.
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Episode 11 of season 4 of Johnny Test: “Dukey Jekyll and Johnny Hyde”. Aired 2009-10-15. Watch it online free on ZapFlix.