Dexter's Laboratory
Dexter, a boy-genius with a secret laboratory, constantly battles his sister Dee Dee, who always gains access despite his best efforts to keep her out, as well as his arch-rival and neighbor, Mandark.

Season 1 · Episode 31 ·
Spacecase
To prevent himself from being taken away by aliens for experimentation, Dexter tricks Dee Dee into going instead, but he regrets his decision after realizing how much he cares for her.
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Episode 31 of season 1 of Dexter's Laboratory: “Spacecase”. Aired 1996-12-18. Watch it online free on ZapFlix.