Dexter's Laboratory
Dexter, a boy-genius with a secret laboratory, constantly battles his sister Dee Dee, who always gains access despite his best efforts to keep her out, as well as his arch-rival and neighbor, Mandark.

Season 4 · Episode 29 ·
The Blonde Leading the Blonde
Dexter refuses to see that blonde's have more fun, so he dyes Dee Dee's hair to prove it.
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Episode 29 of season 4 of Dexter's Laboratory: “The Blonde Leading the Blonde”. Aired 2003-09-19. Watch it online free on ZapFlix.