Dexter's Laboratory
Dexter, a boy-genius with a secret laboratory, constantly battles his sister Dee Dee, who always gains access despite his best efforts to keep her out, as well as his arch-rival and neighbor, Mandark.

Season 3 · Episode 30 ·
Oh, Brother
Dexter uses his newest creation to turn Dee Dee into a boy, but the male version of Dee Dee (Doo Dee) is not as cool as Dexter it would.
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Episode 30 of season 3 of Dexter's Laboratory: “Oh, Brother”. Aired 2002-07-05. Watch it online free on ZapFlix.