Dexter's Laboratory
Dexter, a boy-genius with a secret laboratory, constantly battles his sister Dee Dee, who always gains access despite his best efforts to keep her out, as well as his arch-rival and neighbor, Mandark.

Season 2 · Episode 10 ·
The Koos is Loose
Dee Dee's imaginary friend comes to life and annoys Dexter. Dexter ends up wishing him away, then he realizes he made a terrible mistake.
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Episode 10 of season 2 of Dexter's Laboratory: “The Koos is Loose”. Aired 1997-08-06. Watch it online free on ZapFlix.